In June 2015, Comvita announced the results of a human intervention trial demonstrating for the first time a positive effect between the intake of Comvita's Fresh-Picked™ Olive Leaf Extract (OLE) and positive short-term changes in measures associated with cardiovascular disease (CVD).
The results of the study on fresh olive leaves are published in the British Journal of Nutrition (BJN) and demonstrate for the first time that the application of a single recommended dose of Comvita fresh Olive Leaf Extract (OLE) showed improvements in blood vessel function and a lower inflammatory marker in the blood. This compared to participants that received a placebo. The study was conducted on healthy patients. The positive effect was associated with the absorption of active phenolic components from the Comvita Fresh-Picked Olive Leaf Extract. High levels of the pro-inflammatory marker measured in this study and poor blood vessel function are some of the key contributors to the development of cardiovascular disease (CVD).
Comvita's former CEO Brett Hewlett said: "The two-day, 18 person human intervention study is the latest in an ongoing research programme being undertaken by Comvita in collaboration with the University of Reading and other internationally recognised research institutes. This research programme is exploring the effects of Comvita's Fresh Olive Leaf Extract active phenolic components on supporting healthy cardiovascular function."
Cardiovascular disease continues to be the number one cause of death globally. It has been established that most cardiovascular diseases are preventable via altering diets and lifestyle," said Professor J.P.E Spencer, Hugh Sinclair Unit of Human Nutrition, University of Reading and corresponding author of the study.
"This study was important to explore links between Olive Leaf Extract components in the blood and associate with positive changes in vascular function and pro-inflammatory markers. Longer term epidemiological studies are needed to establish definitive conclusions," said Professor Spencer.
Cardiovascular disease is a class of diseases that involve the heart or blood vessels. Cardiovascular diseases are the leading cause of death globally. Together they resulted in 17.3 million deaths (31.5%) in 2013 up from 12.3 million (25.8%) in 1990. Most cardiovascular diseases are preventable by addressing behavioural risk factors, such as changes to diet and lifestyle. (Source: World Health Organisation).
Mr Hewlett said: "We are involved in a research programme with world leading research organisations to establish links between Olive Leaf Extract and its ability to support cardiovascular and other health functions. A longer and larger study of fresh Olive Leaf Extract targeting cardiovascular health has been conducted with publication expected early in 2016. Additional trials are being considered on cardiovascular disease and other conditions.
The study was conducted by the Hugh Sinclair Unit of Human Nutrition, University of Reading. Funding for the research was equally contributed to by Comvita and an R&D project Grant from Callaghan Innovation, the New Zealand government's business innovation agency. Article Excerpt from: Comvita Olive Leaf Extract Trial.
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